NLM Other uses and applications for PGEs include agricultural, cosmetic, electronic, ink, textile and adhesive products. HHS Please enable it to take advantage of the complete set of features! Propylene Glycol is. P-Series glycol ethers are propylene oxide-based, more hydrophobic, have lower surface tension and lower toxicity, and work well in higher pH systems. Belongs to the Following Reactive Group(s) Formulating with Glycol Ethers Article In the 2-year study, the incidences of exposure-related hepatocellular adenoma, adenoma or carcinoma combined, and hepatoblastoma occurred with a positive trend, and were significantly increased in 1200 ppm groups. Alpha 2u-globulin nephropathy and carcinogenicity following exposure to decalin (decahydronaphthalene) in F344/N rats. DIPROPYLENE GLYCOL BUTYL ETHER . Evaluation of potential human carcinogenicity of the synthetic monomer ethyl acrylate. 2004 Mar;(515):1-306. 1,2'-oxydipropanol dimethyl ether Propylenglycolmonobutylether ist eine farblose Flüssigkeit mit etherischem Geruch, die löslich in Wasser ist. Glycols & Glycol Ethers FBC offers a wide variety of Gycols and Gycol Ethers commonly used in cleaner and paint formulations. Propylene glycol butyl ether, whose demand exceeded 400 kilo tons globally, held the largest market share in 2017. Die Dämpfe von Propylenglycolmonobutylether können mit Luft ein explosionsfähiges Gemisch (Flammpunkt 59 °C, … PubMed:Concentration and determination of the propylene glycol butyl ether esters of 2,4-dichlorophenoxyacetic acid (PGBE 2,4-D) in air. Linear Formula CH 3 (CH 2) 3 OC 3 H 6 OC 3 H 6 OH . Dipropylene Glycol Butyl Ether is the propylene oxide-based glycol ether. It has low water solubility and good coupling and demonstrates good solvency for coating resins. Propylene series glycol ethers are used in surface coatings, leather, pesticides, electrical, industrial cleaners, resins, and printing inks; [ECETOC] Used as a coupling agent and solvent (degreasers, paint removers, metal cleaners, and hard surface cleaners), coalescent (latex coatings), coupling agent (water-based agricultural formulations), and chemical intermediate (epoxides, acid ester derivatives, … Cancer: 06/11/2004. • Ethylene glycol monomethyl ether (2-methoxyethanol, CH3OCH2CH2OH) IGL’s focus is on manufacturing ethyl / butyl glycol ethers and its acetates, which find application in the paint and coating, automotive brake fluid and electronic chemical industries. Asthma/Respiratory . Dipropylene Glycol Butyl Ether is supplied as a product that is >98.5% pure. It is majorly used in products that are used in treating metal and non-metal surfaces, laboratory products, and in water treatment formulation. If you have any questions, comments, or concerns about the content of this page, please click here. Please contact us with questions or to… Recommended use and restrictions on use Use of the substance/mixture : Solvent 1.3. LyondellBasell offers a broad line of glycol ethers based on ethylene and propylene. Evaluation of e-liquid toxicity using an open-source high-throughput screening assay. It is used as a solvent and as a coalescent for water-borne latex coatings. It is a mixture of four isomers. Clipboard, Search History, and several other advanced features are temporarily unavailable. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. The increased use of water-based surface coatings, in which glycol ethers play an important role, has led to the growth of the entire glycol market. Cancer . Propylene glycol mono-t-butyl ether (PGMBE) is used as a solvent in a variety of commercial applications. Propylene glycol tertiary ‐butyl ether (PGTBE) also has been tested and fails to cause these toxicities or birth defects in rats exposed by inhalation to substantial concentrations. Would you like email updates of new search results? 1,2-Propylene glycol 1-monobutyl ether . 89399-28-0. No Data, Some Concern . Tripropylene glycol mono n-butyl ether. NACRES NA.23 Propylene Glycol Ethers (PGEs) are high performance solvents used in numerous industrial applications, including cleaners, inks, paints, and coatings. The EPA requires 59X1IJT82G. These compounds are alkyl ethers which originate from either ethylene glycol (“E-series”) or propylene glycol (“P-series”). Trade names . In the 2-week study, liver weights and in the 14-week study, liver weights and the incidences of centrilobular hypertrophy were increased. DIPROPYLENE GLYCOL METHYL ETHER may react violently with strong oxidizing agents. Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome. Registration dossier . It is approved by the Food and Drug Administration as "an indirect and direct food additive for use as an antimicrobial agent, defoamer, stabilizer and component of adhesives", and also "may be used to wash or assist in the peeling of fruits and vegetables" and "may be safely used as components of articles intended for use in packaging, transporting & holding food". Use restrictions (low), Non-reproductive organ system toxicity (low), and Irritation (skin, eyes, or lungs) (high) fragrance ingredient, solvent, humectant, and viscosity controlling. Listed as Causing Cancer. Propylene glycol mono--butyl ether is used as a solvent in all-purpose cleaners, inks, and nail polish lacquers. Glycols are rarely found in nature but the simple structure especially of propylene glycols (i.e. Effective coupling agent and efficient solvent for water-reducible coatings. Butyl Glycol Ether Revision Date 03/04/2015 Version 1.0 Print Date 03/04/2015 110000002553 Page 2 of 9 SAFETY DATA SHEET Prevention P210 Keep away from heat/sparks/open flames/hot surfaces. What’s so bad about PPG-14 butyl. For example, propylene glycol ethyl ether (PGEE) and its acetate do not cause the critical toxicities of testicular, thymic, or blood injury and do not produce birth defects. PubMed:Solid absorbent collection and gas chromatographic determination of the propylene glycol butyl ether esters of 2,4,5-T in air. EC Number 249-951-5. It is found in antifreeze, most. MDL number MFCD01781688. alpha 2u-globulin nephropathy and renal tumors in national toxicology program studies. In the liver, the incidences of hepatocellular adenomas occurred with a positive trend in male rats, and may have been related to PGMBE exposure. 1-Butoxy-2-propanol . Propylene Glycol N-Butyl Ether is a solvent that can be found in common household kitchen cleaners. Male and female F344/N rats and B6C3F(1) mice were exposed to PGMBE by whole-body inhalation for 2 or 14 weeks (0, 75, 150, 300, 600, or 1200 ppm) or 2 years (0, 75, 300, or 1200 ppm); male NBR rats were exposed for 2 weeks. Propylene Glycol N-propyl Ether Propylene glycol N-propyl ether (PnP) is a colorless liquid with an ether-like odor. Propylene glycol tertiary‐butyl ether (PGTBE) also has been tested and fails to elicit these toxicities or birth defects in rats exposed by inhalation to substantial concentrations. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. 2005 Sep;113(9):1205-8. doi: 10.1289/ehp.7542. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. Cogliano VJ, Grosse Y, Baan RA, Straif K, Secretan MB, El Ghissassi F; Working Group for Volume 88. Propylene Glycol Butyl Ether is the propylene glycol ether of n-butyl alcohol that conforms to the formula: C 7 H 16 O 2 Exposure to PGMBE also produced increases in hepatic tumors in male and female mice. Propylene glycol has been used for over 50 years in a large variety of applications. those who handle it must wear face masks, gloves and goggles. For example, propylene glycol ethyl ether (PGEE) and its acetate do not cause the critical toxicities of testicular, thymic, or blood injury and do not produce birth defects. Environ Health Perspect. Products / Propylene Glycol Ethers Propylene Glycol n-Butyl Ether (PnB) Make an Enquiry Home; Products; Team; Partners; Contact ; General Terms & Conditions ; Rebain International (NL) B.V. Andries Copierhof 1A 3059 LM Rotterdam The Netherlands. Sources/Uses. No Data, Some Concern . Natl Toxicol Program Tech Rep Ser. Propylene glycol mono n-butyl ether . Renal lesions suggestive of alpha(2u)-globulin nephropathy were observed in male F344/N, in the 2 and 14-week studies, no kidney lesions were seen in NBR rats. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. ether? We t studied the effects of propylene glycol mono-t-butyl ether on male and female rats and mice to identify potential toxic or cancer-related hazards to humans. It is used as stabilizer for vitamins, and as a water-miscible cosolvent. Toxicology and carcinogenesis studies of dipropylene glycol in rats and mice. PnP is a propylene oxide-based, or Pseries, glycol ether. As a pharmaceutical additive, propylene glycol is generally regarded as safe. In the 2-year study, male rats displayed exposure-related nonneoplastic lesions in the kidney, and may have shown marginal increases in tubular neoplasms. commercially produced antiperspirants and e-cigarettes. 2018 Jul 1;198(1):67-76. doi: 10.1164/rccm.201710-2033OC. PnP Glycol Ether Propylene Glycol n-Propyl Ether NO 1.5 0.21 118/48 25.4 15.3 4.9 11.2 ∞ Applications Air fresheners and fragrances, cleaner formulations such as glass cleaners, hard surface cleaners, floor cleaners, rust removers, industrial cleaners, and metal cleaners DOWANOL™ TPnB Glycol Ether Tripropylene Glycol n-Butyl Ether PnP is commercially available as a mix of two isomers. Dipropylene glycol monomethyl ether (also known as Methoxy Propoxy Propanol, Oxybispropanol, dipropylene glycol methyl ether, DPM, and Dowanol DPM) is a propylene oxide-based/P series glycol ether and has the formula C 7 H 16 O 3.It is a clear, colourless, viscous liquid which has a slight ether … Propylene Glycol can be found as food grade and is used in certain foods/supplements, it's metabolized into pyruvic acid, acetic acid, lactic acid and propionaldehyde. commercially produced antiperspirants and e-cigarettes. Molecular Weight 190.28 . Propylene glycol (CH8O2) is a commonly used drug solubilizer in topical, oral, and injectable medications. Hooth MJ, Herbert RA, Haseman JK, Orzech DP, Johnson JD, Bucher JR. Toxicology. 2-methoxy-1-methylethyl acetate, 2propanol, 1methoxy, acetate, methoxyisopropyl acetate, propylene glycol methyl ether acetate, and propylene glycol monomethyl ether acetate Cancer Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Propylene Glycol Butyl Ether is a propylene glycol ether of n-butyl alcohol. Ethoxydiglycol, the ethyl ether of diethylene glycol, contains only one hydroxyl group. Supplier EC Number 225-878-4. used as a PENETRATION enhancer. Continuing changes in E-series glycol ether products: In the major regions of the world, growth has been primarily for the butyl products (and some smaller-volume specialty glycol ethers); the methyl and ethyl products groups have been in decline. In mice of both sexes, the major target of PGMBE toxicity was the liver. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. 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